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Promotional portrait of cast members from the television series, "E.R.," c. 1996. L-R: Noah Wyle, Sherry Stringfield, Anthony Edwards, Julianna Margulies, George Clooney, Gloria Reuben and Eriq La Salle.

The cast of ER will reunite on Stars In The House for a special Earth Day episode for Waterkeeper Alliance.

Gloria Reuben organized the cast to return one more time, as the President of Waterkeeper Alliance, CNN Entertainment reports. Reuben played physician assistant Jeanie Boulet on the show.

Reuben will be joined by George Clooney, who played Dr. Doug Ross, Noah Wyle (John Carter), Laura Innes (Kerry Weaver), Anthony Edwards (Mark Greene), Alex Kingston (Elizabeth Corday), Julianna Margulies (Carol Hathaway), Goran Visnjic (Luka Kovac), Paul McCrane (Robert Romano), Ming-Na Wen (Jing-Mei Chen), Laura Cerón (Chuny Marquez), Yvette Freeman (Haleh Adams), Conni Marie Brazelton (Connie Oligario), and C.C.H. Pounder (Angela Hicks) for a night of nostalgia about their time at Chicago’s County General Hospital.

56-year-old Reuben said in an announcement for the event, “I am absolutely thrilled to be reuniting with my ER family for a cause that is so close to my heart, and so grateful to Seth and James for allowing us to use their incredible platform to do so,”

The reunion will stream on April 22 at 8 p.m. EST on People magazine’s official Facebook, Twitter, and YouTube, as well as on PeopleTV’s Facebook and Twitter, and on the Stars In The House YouTube channel, and StarsInTheHouse.com.

Fans will be able to ask questions live and donate to Waterkeeper Alliance. Waterkeeper is the fastest growing global nonprofit focused solely on clean water.